Abstract
Ribosomal encoded bacteriocins (25-80 kDa) are the secretory proteins which inhibit the growth of closely related bacteria. Their transcriptions are regulated under different environmental conditions and have different modes of action which includes non specific DNase activity, specific RNase activity, pore forming and inhibition of murein synthesis in bacteria. In this article we have summarized the genetic organization, regulation, structural organization, reception and functional activities of ribosomal encoded bacteriocins only and does not discuss peptide bacteriocins and microcins (<10 kDa). In the end of article practical applications of these bacteriocins has been described such as potential antitumor agent of their catalytic domain, biosensor for genotoxicity by exploiting their promoters and their effectiveness against HIV infection.
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