Abstract
Abstract A protected heptapeptide corresponding to sequence 24–30 of ribonuclease T1, namely benzyloxycarbonyl-O-benzyl-l-tyrosyl-l-glutaminyl-l-leucyl-l-histidyl-γ-t-butyl-l-glutamyl-β-t-butyl-l-aspartyl-glycine ethyl ester (XI), was synthesized by coupling of benzyloxycarbonyl-O-benzyl-l-tyrosyl-l-glutaminyl-l-leucine azide with a tetrapeptide ester, l-histidyl-γ-t-butyl-l-glutamyl-β-t-butyl-l-aspartyl-glycine ethyl ester, which is derived from Nα,Nim-dibenzyloxycarbonyl tetrapeptide ester by the catalytic hydrogenolysis. These tri- and tetrapeptide components were prepared with stepwise syntheses free from racemization.
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