Abstract
We present a rhodium-catalysed ring-opening reaction of heterobicyclic alkenes with indole and pyrrole nucleophiles, resulting in 1,2-disubstitued trans-dihydronaphthalene cores in up to a 95% yield as a single diastereomer. The Rh-catalysed reaction demonstrated tolerance for a broad scope of nucleophiles as well as various heterobicyclic alkenes. Notably, the reaction was successful with substrates that previously performed poorly or failed under iridium catalysis. This reaction is 100% atom-economic and offers C–C bond formation without prior functionalization of the coupling partners.
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