Abstract
AbstractA cascade C−H activation, annulation, and etherification of N‐hydroxybenzamides with propargylamines provides a flexible route to N‐alkoxylated 3‐arylisoindolin‐1‐ones. Three new bonds (C−C, C−N, and C−O) are generated to afford a series of isoindolin‐1‐ones bearing a tetrasubstituted carbon in 49–82% yield. The utility of this method was showcased by gram‐scale synthesis and synthetic transformations of the product to access structurally diverse isoindolinones.magnified image
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