Rhetorical Strategies Used in the Reporting of Implantable Defibrillator Primary Prevention Trials

Implantable Defibrillators for Primary Prevention of Sudden Death in Patients on Dialysis

The past, present, and future of the implantable cardioverter defibrillator

The ESC Risk Score Is Less Reliable than ACC/AHA Risk Factors in Hypertrophic Cardiomyopathy: When Sensitivity Trumps Specificity

Can we predict, prevent, and minimize defibrillator shocks? Lessons learned from “remote monitoring”

Recurrent orthostatic syncope due to left atrial and left ventricular collapse after a continuous-flow left ventricular assist device implantation

Managing atrial fibrillation in the CRT patient: Controversy or consensus?

Unusual case of late dislodgment of a superior vena cava coil

Cardiac resynchronization therapy (CRT): Clinical trials, guidelines, and target populations

Association Between Bilirubin and Mode of Death in Severe Systolic Heart Failure

Contemporary and future trends in cardiac resynchronization therapy to enhance response

Endoscopy in patients with implanted electronic devices

“Please implant a defibrillator in my patient”: It's déjà vu all over again

2021 PACES Expert Consensus Statement on the Indications and Management of Cardiovascular Implantable Electronic Devices in Pediatric Patients: Executive Summary.

Epicardial multisite conduction blocks detected by equispaced electrode array and omnipolar technology in Brugada syndrome

Bone morphogenetic protein 10 (BMP10) belongs to the TGFβ-superfamily. Previously, we had demonstrated that BMP10 is a key regulator for ventricular chamber formation, growth, and maturation. Ablation of BMP10 leads to hypoplastic ventricular wall formation, and elevated levels of BMP10 are associated with abnormal ventricular trabeculation/compaction and wall maturation. However, the molecular mechanism(s) by which BMP10 regulates ventricle wall growth and maturation is still largely unknown. In this study, we sought to identify the specific transcriptional network that is potentially mediated by BMP10. We analyzed and compared the gene expression profiles between α-myosin heavy chain (αMHC)-BMP10 transgenic hearts and nontransgenic littermate controls using Affymetrix mouse exon arrays. T-box 20 (Tbx20), a cardiac transcription factor, was significantly up-regulated in αMHC-BMP10 transgenic hearts, which was validated by quantitative RT-PCR and in situ hybridization. Ablation of BMP10 reduced Tbx20 expression specifically in the BMP10-expressing region of the developing ventricle. In vitro promoter analysis demonstrated that BMP10 was able to induce Tbx20 promoter activity through a conserved Smad binding site in the Tbx20 promoter proximal region. Furthermore, overexpression of Tbx20 in myocardium led to dilated cardiomyopathy that exhibited ventricular hypertrabeculation and an abnormal muscular septum, which phenocopied genetically modified mice with elevated BMP10 levels. Taken together, our findings demonstrate that the BMP10-Tbx20 signaling cascade is important for ventricular wall development and maturation.