Abstract
Heterospecific pregnancy is generally believed to protect the mother against Rh sensitization and not to protect the child against Rh hemolytic disease. This study shows that: (1) Rh hemolytic disease was less severe in 126 infants ABO incompatible with their mothers than in 366 compatible infants. The 126 included 53 with combined Rh and ABO hemolytic disease and 73 with only Rh hemolytic disease. Since the height of the maternal Rh titer was not solely responsible for the mildness, it is suggested that possibly Rh antibody is retained in the placenta and related to the binding of anti-A or -B. (2) The sensitization caused by heterospecific pregnancy in 22 per cent of the mothers analyzed showed low titer Rh antibody, which indicates only partial protection by heterospecific pregnancy.
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