Abstract
In this literature review, we will introduce all reported methods that have been developed for determination of the antihistaminic drug, olopatadine HCl, the cough suppressant drug oxeladine citrate, and certain antihypertensive drugs such as amlodipine besylate and xipamide in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of allergy and hypertension.
Highlights
Methods of determinationSpectroscopic methods: A novel simple, accurate, sensitive and economical spectrophotometric method has been established and validated for the determination of the antihistaminic drug, olopatadine hydrochloride in both pure form and eye drops [3]
Olopatadine Hydrochloride is the hydrochloride salt form of olopatadine
A rapid and sensitive liquid chromatography tandem mass spectrometry method was performed for determination of olopatadine concentration in human plasma [12]
Summary
Spectroscopic methods: A novel simple, accurate, sensitive and economical spectrophotometric method has been established and validated for the determination of the antihistaminic drug, olopatadine hydrochloride in both pure form and eye drops [3]. UV spectrophotometric estimation of olopatadine hydrochloride in bulk and pharmaceutical dosage form by area under curve and second order derivative methods was developed [9] In this method the standard and sample solutions of olopatadine hydrochloride were prepared in methanol. Miscellaneous methods: Two novel potentiometric sensors were developed for the quantification of olopatadine hydrochloride and oxeladine citrate in pure forms, pharmaceutical preparations and human plasma [24]. The both sensors were fabricated on incorporating the olopatadine and oxeladine tetraphenylborate ion-pairs as electroactive materials in plasticized poly (vinyl chloride) matrix membranes with o-nitrophenyl octyl ether. Delivery to the myocardial tissue, and decreased total peripheral resistance [18]
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