Abstract
Motor neuron disease (MND) is mostly associated with an irreversible course. Spontaneous recovery has been rarely reported. Herein described is a case of a spontaneous recovery of a lower motor neuron disease. A 38-year-old man complained of an insidious onset of weakness in the right upper limb that progressed to the lower limbs in 16 months. Physical examination revealed mild dysphonia, dysphagia, fasciculations, global hypotonia without prominent atrophy, proximal and distal tetraparesis. The patient was wheelchair-bound. EMG revealed signs of recent and chronic denervation involving bulbar, axial and appendicular myotomes with abundant pos itive sharp waves and fibrillations potentials in all muscles tested. In two year follow-up, the patient evolved with complete recovery and a new EMG study was completely normal. Reversible MND is a condition rarely reported, but physicians should keep in mind the possibility of its occurrence. J Neurol Res. 2013;3(1):40-41 doi: https://doi.org/10.4021/jnr171w
Highlights
The term ‘motor neuron disease’ (MND) is mostly associated with an irreversible progression of motor symptoms to death in few years
Our case illustrates a spontaneous remission of Motor neuron disease (MND), defined by clinical and electroneuromyographic studies
Mulder and Howard [6] reported that, during the period of 20 years examining more than 2,000 patients with amyotrophic lateral sclerosis (ALS), they had seen “several” patients who were initially diagnosed with ALS but subsequently recovered
Summary
The term ‘motor neuron disease’ (MND) is mostly associated with an irreversible progression of motor symptoms to death in few years. After the progression of the weakness to the lower limbs in one year and four months, he was first evaluated at our clinic Articles © The authors | Journal compilation © J Neurol Res and Elmer PressTM | www.neurores.org Treatment with Riluzole 50 mg twice a day was started in February 2010, but adverse effects such as gastric intolerance prompted its withdrawal shortly after At this time, the patient mentioned improvement in swallowing and in a 3 month-follow up consultation he denied any dysphagia.
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