Abstract
ABSTRACT A derivative of corticotrophin with acetylated amino groups and hydroxyl groups in serine was used. Acetylated corticotrophin significantly decreased the 17-hydroxycorticosteroid (17-OHCS) level in the plasma of guineapigs 4 hours after the i. m. injection of the derivative in a dose equal to 2.5 USP units of the active hormone per 100 g of body weight. The mean plasma 17-OHCS concentration before the injection of the derivative was 44 ± 2.15 μg/100 ml. After the injection of acetylated corticotrophin, the fall in 17-OHCS content was highly significant, the average level being decreased to 61 %. However, in 12 out of 36 animals there was a fall to 30 % of the initial level. The derivative obtained may be considered as an »anahormone«, and probably has the ability to inhibit the secretion of endogenous corticotrophin.
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