Reversal of End Diastolic Flow in Anterior Cerebral Artery in Late-Onset Neonatal Sepsis

Abstract

Hemodynamics in neonatal sepsis is complex and poorly understood. Circulatory abnormalities are variable from vasodilatation with increased systemic blood flow to vasoconstriction with decreased blood flow, volume depletion or myocardial depression. Cerebral hemodynamics changes in neonatal sepsis. Most studies on cerebral hemodynamics in neonatal sepsis till now have been conducted on early-onset neonatal sepsis, and most of them have shown increased cerebral blood flow with a decreased resistive index (RI) in sepsis. Only a few studies have documented decreased cerebral flow in neonatal sepsis. Here we report a case of late-onset neonatal sepsis with the reversal of end diastolic flow, leading to increased RI associated with the death of the infant.