Abstract
Streptozotocin-diabetic rats showed reduced motor nerve conduction velocity, impaired orthograde axonal transport of choline acetyltransferase, and accumulated sorbitol in the sciatic nerve compared with age-matched controls. Another age-matched group, with diabetes of similar intensity, but treated daily with an aldose reductase inhibitor, showed none of these neurological defects. These findings implicate aldose reductase activity in the development of acute conduction and axonal transport defects in experimental diabetes.
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