Abstract
Objective To discuss the effects of total parathyroidectomy (TPTX) combined with forearm autotransplantation (AT) on patients with chronic kidney disease stage 5 (CKD-5) with secondary hyperparathyroidism (SHPT). Methods Eight-six patients with CKD-5 who underwent TPTX+ AT were selected, levels of blood calcium, serum phosphatase, alkaline phosphatase (ALP), blood impact segment parathyroid hormone (iPTH) before and after operation were detected and analyzed. Clinical symptoms like preoperative ostealgia and postoperative remission were analyzed. Results Postoperative pathological results suggested 224 cases of parathyroid hyperplasia, 119 cases of parathyroid adenoma. There were significant differences in levels of serum calcium, serum phosphatase and iPTH before and after operation (all P<0.01), and there was significant difference in preoperative alkaline phosphatase before and half year after operation (P<0.01). Conclusions TPTX+ AT can effectively block SHPT and alleviate ostealgia and other symptoms. Key words: Chronic kidney disease; Secondary hyperparathyroidism; Parathyroidectomy; Autotransplantation
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