Abstract
We performed a retrospective chart review of 245 patients with papillary thyroid microcarcinoma (PTMC) to define factors linked to central lymph node metastasis and thus prognosis. Univariate and multivariate analyses showed that being male (p < 0.001), age <45 years at diagnosis (p = 0.045), maximum tumor size > 5 mm (p = 0.030), multifocal tumor (p = 0.040) and tumor envelope invasion (p < 0.001) were all independent risk factors for central compartment lymph node metastasis. Unifocal lesions at the thyroid gland’s upper pole, middle and lower pole, had lymph node metastasis rates of 22.7%, 14.0% and 35.0%, respectively (p = 0.048). The rate of central lymph node metastasis was much higher when there was bilateral thyroid involvement than with multifocal unilateral lesions (58.6% vs 37.5%; p = 0.040). These results suggest that for patients at low risk of central lymph node metastasis, unilateral thyroid lobe and isthmus resection is sufficient. However, for patients at high risk of central lymph node metastasis, central lymph node dissection increases the likelihood of complete tumor excision.
Highlights
Papillary thyroid microcarcinomas (PTMCs) are small papillary thyroid carcinomas with maximum diameters less than 1.0 cm
We retrospectively reviewed the surgical treatment of PTMC and analyzed factors that could affect prognosis, including metastasis of central compartment lymph nodes
Univariate analyses showed that the risk factors for cervical lymph node metastasis in PTMC patients included being male, the diagnosed at 5 mm, multifocal tumor, and tumor envelope invasion (Table 1)
Summary
Papillary thyroid microcarcinomas (PTMCs) are small papillary thyroid carcinomas with maximum diameters less than 1.0 cm. Univariate and multivariate analyses showed that being male (p < 0.001), age 5 mm (p = 0.030), multifocal tumor (p = 0.040) and tumor envelope invasion (p < 0.001) were all independent risk factors for central compartment lymph node metastasis. We retrospectively reviewed the surgical treatment of PTMC and analyzed factors that could affect prognosis, including metastasis of central compartment lymph nodes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.