Abstract
BackgroundIt is meaningful to expand the available population information on forensic medicine and to investigate the genetic characteristics of Han population from Jilin Province, Northeast China.MethodsIn this study, we investigated the genetic characteristics of 24 Y‐chromosomal short tandem repeat (STR) loci in 1,088 unrelated Chinese Han male individuals from Jilin Province, using DNATyperTM Y24 amplification kit. Additionally, we performed the population comparison between the Jilin population and the other nine reported populations based on the Y‐STR genotyping haplotypes.ResultsA total of 1,067 different haplotypes were found from 1,088 unrelated individuals, of which 1,046 were unique and 21 were shared by two individuals. The gene diversity values of 22 loci ranged from 0.3870 (DYS391) to 0.9668 (DYS385ab). The random match probability was 0.0010 with the discrimination capacity of 0.9807. Population comparison showed that there were minor differences compared to Beijing Chinese Han, China Manchu, Gansu Chinese Han, and Jiangsu Chinese Han, but major differences with respect to the populations of Guangdong Chinese Han, Yunnan Chinese Han, China Hui, China Korean, and China Tibetan.ConclusionOur results showed that the 24 Y‐STR loci in Jilin Han population are valuable for forensic application and human genetics.
Highlights
It is meaningful to expand the available population information on forensic medicine and to investigate the genetic characteristics of Han population from Jilin Province, Northeast China
The results showed that the 24 Y‐short tandem repeat (STR) loci exhibited the good polymorphic distributions and personal identification capability, which can be applied in the forensic field
Our haplotype data were compared with the nine populations submitted to the YHRD database (Release 55) including Beijing Chinese Han (Nothnagel et al, 2017), Gansu Chinese Han (Yao et al, 2016), Guangdong Chinese Han (Wang et al, 2016), Jiangsu Chinese Han (Li, Yu, Li, Jin, & Yan, 2016), Yunnan Chinese Han (Yanmei et al, 2010), Ningxia Chinese Han (Zhu et al, 2006), China Korean (YA004289), China Manchu (He & Guo, 2013), and China Tibetan (Zhu et al, 2008)
Summary
Short tandem repeats (STRs) are being widely used in forensic DNA analysis, considering that they are diversely distributed in the human genome and present the high discrimination power among the individuals (Yao & Wang, 2016; Zhu et al, 2015). STR, as the common genetic markers in forensic DNA analysis, can provide a great powerful discrimination capability They can be usually utilized in the fields of personal identification and paternity testing (Chen et al, 2017; Guo, 2017; He, Wang, Liu, Hou, & Wang, 2018). The analysis of Y‐chromosomal short tandem repeat (Y‐ STR) has been widely used in forensic investigation and paternity testing on account of its male‐specific characteristic and paternal genetic model (Ballantyne et al, 2014; Jobling, Pandya, & Tyler‐Smith, 1997). It can be applied for inferring the biological sex of a crime scene trace donor. In order to better understand the genetic and structure and background of the Jilin Han population, we performed the population comparison with the other ethnic groups based on the genetic distances generated by the observed gene allelic frequencies
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