Abstract
BackgroundThere is no clear evidence for the target value of blood pressure control after Percutaneous coronary intervention (PCI). Therefore, our study was designed to explore the relationship between blood pressure after PCI and major adverse cardiac events (MACE) during 3-year follow-up.MethodsThis study is a prospective study. We included the patients who were diagnosed with acute coronary syndrome and underwent PCI stent implantation operation. The study initially collected information of 552 patients. The start and end times of the study are from January 1, 2017 to December 31, 2020. The independent variables of this study are the average systolic blood pressure and the average diastolic blood pressure after PCI. The dependent variable is the occurrence of MACE events in patients within 3 years after PCI. MACE is defined as acute myocardial infarction, recurring chest pain, heart failure, stroke, revascularization and cardiac death.ResultsA total of 514 subjects met the inclusion criteria. The average age of the study subjects is 61.92 ± 9.49 years old, of which 67.12% are male. 94 subjects had a MACE event within 3 years, and the occurrence rate was 18.29%. There is no significant non-linear or linear relationship between diastolic blood pressure and MACE events. There is a curvilinear relationship between the average systolic blood pressure of patients after PCI and MACE events within 3 years and the inflection point is 121. On the left side of the inflection point, the effect size and 95% CI are 1.09 and 1.01–1.18, respectively (P = 0.029). The impact size and 95% CI at the right inflection point were 1.00 and 0.98–1.02(P = 0.604), respectively.ConclusionThere is a curvilinear relationship between systolic blood pressure and prognosis of patients after PCI. Under the premise of ensuring the safety of patients, maintaining lower blood pressure after surgery is beneficial to improve the prognosis of patients.
Highlights
Hypertension is one of the important risk factors of coronary atherosclerosis [1,2,3]
We believe that the control of blood pressure after Percutaneous coronary intervention (PCI) is of great significance to improve the clinical outcome of patients
The purpose of this study is to explore the relationship between the systolic and diastolic blood pressure after surgery and the occurrence of major adverse cardiac events (MACE) events within 3 years of patients undergoing PCI in China
Summary
Hypertension is one of the important risk factors of coronary atherosclerosis [1,2,3]. The guidelines recommend that the blood pressure of patients with hypertension should be strictly controlled [4, 5]. We believe that the control of blood pressure after PCI is of great significance to improve the clinical outcome of patients. There is no clear evidence for the target value of blood pressure control within short term after stent implantation. There is currently no research evidence about the correlation between blood pressure and clinical prognosis in Chinese patients after PCI. There is no clear evidence for the target value of blood pressure control after Percutaneous coronary intervention (PCI). Our study was designed to explore the relationship between blood pressure after PCI and major adverse cardiac events (MACE) during 3-year follow-up
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