Retinoids may increase fibrotic potential of TGF-β: Crosstalk between two multi-functional effectors

Abstract

HepatologyVolume 26, Issue 4 p. 1067-1068 EditorialFree Access Retinoids may increase fibrotic potential of TGF-β: Crosstalk between two multi-functional effectors R Blomhoff, R BlomhoffSearch for more papers by this author R Blomhoff, R BlomhoffSearch for more papers by this author First published: 30 December 2003 https://doi.org/10.1002/hep.510260439Citations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1 Wake K. Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs. Int Rev Cytol 1980; 66: 303– 353. 2 Blomhoff R, Wake K. Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J 1991; 5: 271– 277. 3 Friedman SL. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993; 328: 1828– 1835. 4 Davis BH, Kramer RT, Davidson NO. Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production. J Clin Invest 1990; 86: 2062– 2070. 5 Davis BH, Vucic A. The effect of retinol on Ito cell proliferation in vitro. Hepatology 1988; 8: 788– 793. 6 Sato T, Kato R, Tyson CA. Regulation of differentiated phenotype of rat hepatic lipocytes by retinoids in primary culture. Exp Cell Res 1995; 217: 72– 83. 7 Senoo H, Wake K. Suppression of experimental hepatic fibrosis by administration of vitamin A. Lab Invest 1985; 52: 182– 194. 8 Seifer WF, Bosma A, Hendriks HF, van Leeuwen RE, van Thil-de Ruiter GC, Seifert-Bock I, Knock DL, et al. Beta-carotene (provitamin A) decreases the severity of CCl4-induced hepatic inflammation and fibrosis in rats. Liver 1995; 15: 1– 8. 9 Seifer WF, Bosma A, Brouwer A, Hendriks HF, Roholl PJ, van Leeuwen RE, Ruiter GC van Thil-de, et al. Vitamin A deficiency potentiates carbon tetrachloride-induced liver fibrosis in rats. Hepatology 1994; 19: 193– 201. 10 Okuno M, Moriwaki H, Imai S, Muto Y, Kawada N, Suzuki Y, Kojima S. Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-β in liver stellate cells. Hepatology 1997; 26: 918– 926. 11 Blomhoff R. Vitamin A in Health and Disease. New York: Marcel Dekker, Inc., 1994: 1– 677. 12 Blomhoff R, Green MH, Berg T, Norum KR. Transport and storage of vitamin A. Science 1990; 250: 399– 404. 13 Blomhoff R, Helgerud P, Rasmussen M, Berg T, Norum KR. In vivo uptake of chylomicron retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells. Proc Natl Acad Sci U S A 1982; 79: 7326– 7330. 14 Blomhoff R, Rasmussen M, Nilsson A, Norum KR, Berg T, Blaner WS, Kato M, et al. Hepatic retinol metabolism, distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells. J Biol Chem 1985; 260: 13560– 13565. 15 Blaner WS, van Bennekum AM, Brouwer A, Hendriks HF. Distribution of lecithin-retinol acyltransferase activity in different types of rat liver cells and subcellular fractions. FEBS Lett 1990; 274: 89– 92. 16 Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Kastner P, Mark M, et al. The nuclear receptor superfamily: the second decade. Cell 1995; 83: 835– 839. 17 Ohata M, Lin M, Satre M, Tsukamoto H. Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis. Am J Physiol 1997; 272: G589– G596. 18 Takahashi N, Bretiman TR. Retinoylation of proteins in mammalian cells, pp. 257– 273. In: R Blomhoff, ed. Vitamin A in Health and Disease. New York: Marcel Dekker, Inc., 1994: 257–273. 19 Koga H, Fujita I, Miyazaki S. Effects of all-trans retinoic acid on super-oxide generation in intact neutrophils and a cell-free system. Br J Haematol 1997; 97: 300– 305. 20 Buck J, Derguini F, Levy E, Nakanishi K, Hmmerling U. Intracellular signalling by 14-hydroxy-4, 14-retro-retinol. Science 1991; 254: 1654– 1656. 21 Achkar CC, Derguini F, Blumberg B. 4-oxoretinol, a new natural ligand and transactivator of the retinoic acid receptors. Proc Natl Acad Sci USA 1996; 93: 4879– 4884. Citing Literature Volume26, Issue4October 1997Pages 1067-1068 ReferencesRelatedInformation