Abstract
Retinoids at low concentrations strikingly enhance the growth-promoting activity of polypeptides like epidermal growth factor, insulin, vasopressin and fibroblast-derived growth factor and of 12-0-tetradecanoyl-phorbol-13-acetate, a potent tumour-promoting agent. Retinoids enhance both DNA synthesis and cell proliferation in quiescent cultures of mouse 3T3 cells and of hamster Nil-8 cells. These findings contrast with previous reports showing growth inhibitory properties of retinoids.
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