Abstract
The retentions of 45 barbituric acid derivatives were determined on a β-cyclodextrin (β-CD) polymer-coated silica column using unbuffered methanol—water, ethanol—water, acetonitrile—water, dioxane—water and tetrahydrofuran—water eluent mixtures. Stepwise regression analysis indicated that the retention of barbituric acid derivatives is mainly governed by the lipophilicity, molar refractivity (related to the solute volume) and to a lesser extent by the electronic parameters of substituents in each eluent system, suggesting the significant importance of these physico-chemical parameters in the determination of retention behaviour. The spectral map technique indicated that the solvent strength and selectivity of organic modifiers on a β-CD polymer-coated silica column depended on their bulkiness and electronic parameters, respectively.
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