Abstract
Objective To investigate whether the effect of resveratrol improved inflammatory response on acute myocardial infarction (AMI) was mediated by silencing information regulator 1/nuclear factor kappa B (SIRT-1/NF-κB) pathway in rats. Methods Totally 30 adult Sprague Dawley rats were randomly assigned to 3 groups: Sham group, AMI group, Resveratrol group; Four weeks later, qRT-PCR and Western blot were used to detect the expression of mRNA and protein of interleukin (IL)-1β, interleukin(IL)-6 and silent information regulator 1(SIRT)-1 on the intersection area of infract heart tissue. Western blot was also used to detect the protein expression of IKK, P-IKK, p65 and p-p65 in the junction of cardiac infarction. Results Compared with Sham group, the expression of mRNA and protein of IL-1β, IL-6 were significantly increased (all P 0.05). Conclusion Resveratrol can improve inflammatory response through the SIRT-1/NF-κB pathway after acute myocardial infarction in rats. The mechanism may be related to SIRT-1 activated by Resveratrol prevented phosphorylation of IKK and p65, thus inhibited the activation the NF-κB pathway. It may have a cardioprotective effect. Key words: Resveratrol; Acute myocardial infarction; Silencing information regulator 1; nuclear factor kappa B
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