Abstract
The use of polyphenols as adjuvants in lowering risk factors for various debilitating diseases has been investigated in recent years due to their possible antioxidant action. Polyphenols represent a fascinating and relatively new subject of research in nutraceuticals and nutrition, with interest rapidly expanding since they can help maintain health by controlling metabolism, weight, chronic diseases, and cell proliferation. Resveratrol is a phenolic compound found mostly in the pulp, peels, seeds, and stems of red grapes. It has a wide variety of biological actions that can be used to prevent the beginning of various diseases or manage their symptoms. Resveratrol can influence multiple inflammatory and non-inflammatory responses, protecting organs and tissues, thanks to its interaction with immune cells and its activity on SIRT1. This compound has anti-inflammatory, antioxidant, anti-apoptotic, neuroprotective, cardioprotective, anticancer, and antiviral properties, making it a potential adjunct to traditional pharmaceutical therapy in public health. This review aims to provide a comprehensive analysis of resveratrol in terms of active biological effects and mechanism of action in modifying the immune cellular response to promote human psychophysical health.
Highlights
Diet and proper lifestyle play a key role in maintaining well-being and preventing diseases
This review aims to provide a comprehensive analysis of resveratrol in terms of active biological effects and mechanism of action in modifying the immune cellular response to promote human psychophysical health
The purpose of this review is to provide a detailed assessment of the active biological effects and of the mechanism of action of RSV in modulating the immune cellular response to improve human psychophysical health
Summary
Diet and proper lifestyle play a key role in maintaining well-being and preventing diseases. RSV has antioxidant, anticarcinogenic, anti-inflammatory, neuroprotective, cardioprotective, and anti-aging properties [10,11] This natural flavonoid can mitigate toxicities related to chemo-radiation therapy in normal tissues [12] and enhance migration of cells toward injured areas, which is important from therapeutic standpoints [13]. It has been described that RSV can activate the Silent Information Regulator 1 (SIRT1), a type of histone deacetylase, to protect neurons against apoptosis, inflammation, and oxidative stress in the treatment of neurological disorders such as Parkinson’s disease [20]. It modulates cholinesterase activity and preserves dopaminergic neurons, which enhance learning and memory. The purpose of this review is to provide a detailed assessment of the active biological effects and of the mechanism of action of RSV in modulating the immune cellular response to improve human psychophysical health
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