Abstract
BackgroundThe resumption of menses (ROM) is considered an important clinical marker in weight restoration for patients with anorexia nervosa (AN). The purpose of this study was to examine ROM in relation to expected body weight (EBW) and psychosocial markers in adolescents with AN.MethodsWe conducted a retrospective chart review at The University of Chicago Eating Disorders Program from September 2001 to September 2011 (N = 225 females with AN). Eighty-four adolescents (Mean age = 15.1, SD = 2.2) with a DSM-IV diagnosis of AN, presenting with secondary amenorrhea were identified. All participants had received a course of outpatient family-based treatment (FBT), i.e., ~20 sessions over 12 months. Weight and menstrual status were tracked at each therapy session throughout treatment. The primary outcome measures were weight (percent of expected for sex, age and height), and ROM.ResultsMean percent EBW at baseline was 82.0 (SD = 6.5). ROM was reported by 67.9% of participants (57/84), on average at 94.9 (SD = 9.3) percent EBW, and after having completed an average of 13.5 (SD = 10.7) FBT sessions (~70% of standard FBT). Compared to participants without ROM by treatment completion, those with ROM had significantly higher baseline Eating Disorder Examination Global scores (p = .004) as well as Shape Concern (p < .008) and Restraint (p < .002) subscale scores. No other differences were found.ConclusionsResults suggest that ROM occur at weights close to the reference norms for percent EBW, and that high pre-treatment eating disorder psychopathology is associated with ROM. Future research will be important to better understand these differences and their implications for the treatment of adolescents with AN.
Highlights
The resumption of menses (ROM) is considered an important clinical marker in weight restoration for patients with anorexia nervosa (AN)
In an exploratory analysis we compared this subset of patients (n = 10) to those with ROM after reaching 95% of expected body weight (EBW) on length of illness (LOI), percent of EBW at baseline, amount of weight gained
Findings from this study underscore the need for full weight restoration based on EBW as a primary treatment goal for the pediatric eating disorder populations
Summary
The resumption of menses (ROM) is considered an important clinical marker in weight restoration for patients with anorexia nervosa (AN). It has been shown that pre-pubertal weight can be a useful tool to determine the weight at which resumption of menses (ROM) is likely to occur in adolescents with AN, highlighting the need to return to a weight trajectory preceding weight loss [18]. ROM does depend on reaching goal weight, as endocrine markers such as luteinizing hormone, estradiol, and triiodothyronine can be useful in determining the onset or return of menses [3,18,21,22]. Notwithstanding, ROM, in conjunction with expected body weight (EBW), can serve as a yardstick to estimate goal weights for adolescent AN. What differentiates patients at a minimally healthy weight with and without ROM remains unclear
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