Abstract
A post hoc analysis using individual patient data to evaluate the effects of selective serotonin reuptake inhibitor (SSRI) antidepressants has found that when using the core depression measures of the Hamilton Depression Rating Scale (HDRS), SSRIs are as effective for nonsevere depression as they are for severe depression. These results contradict those of other analyses that have based their findings on all 17 measures of the HDRS, including those for symptoms that are not present to a great degree in patients with nonsevere depression. Study results were published online July 11 in The Lancet Psychiatry.
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