Abstract
Besides improving patients' outcome, decreasing the burden of cancer treatment is the most pertinent aim in breast cancer care today. In both respects, major advances have been achieved in the past 20 years, and HER2-positive breast cancer is one shining example. The introduction of monoclonal antibodies and, more recently, the antibody–drug conjugate trastuzumab–emtansine have gradually improved both pathological complete response rates and long-term outcomes in patients with early-stage disease as well as overall survival in the metastatic setting.
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