Abstract
The prevalence of overweight and obesity among women in Uzbekistan is 31.7 %. There is an annual increase in people with obesity. The facts of the negative impact of fat mass on the hormonal system and, as a result, a decrease in fertility in women are not in doubt. The purpose of this study was to evaluate the results of Metformin use in overweight and obese women of reproductive age. The study included 45 women of reproductive age who could not reduce weight with diet therapy. All patients were divided into three groups: group 1-planning pregnancy (n = 15), group 2 – having abnormal weight gain after childbirth (n = 15), group 3 – having overweight and obesity not related to pregnancy and childbirth (n = 15). Weight loss while taking Metformin increases fertility and should be performed in obese women as pre-gravidar training.
Highlights
Infertility in marriage is one of the most important and complex medical, sociodemographic and economic problems
The results of the study and their discussion were divided into four groups: overweight (n = 6) with a body mass index (BMI) of 27.3 ± 2.2 kg/m2; obese 1 degree (n = 21) with a BMI of 33.7 ± 1.1 kg/ m2; obese 2 degree (n = 13) with a BMI of 37.4 ± 2.3 kg/m2; obese 3 degree (n = 5) with a BMI of 44.1 ± 2.6 kg/m2
Weight reduction was observed in the group of obesity 1 degree in 100 % (n = 6) 7.2 + 0.6 kg (BMI of 29.2 ± ± 0.7 kg/m2); in the group of obesity of 2 degrees 76 % (n = 16) 8.8 ± 0.7 kg (BMI of 33.6 ± 0.8 kg/m2); in the group of obesity grade 3 in 60 % (n = 3) 9.6 ± 1.0 kg (BMI of 35.1 ± 2.1 kg/m2)
Summary
Infertility in marriage is one of the most important and complex medical, sociodemographic and economic problems. The frequency of infertile marriages in many countries of the world ranges from 8 to 29%. In Europe, infertility affects about 10% of married couples, in the United States – 15%, in Canada-17%, the share of infertile marriages in. Who has adjusted the definition of infertility, which is considered as the absence of pregnancy for one year of regular sexual activity without the use of contraception (who, 2009). According to the European society for female reproduction and embryology (ESHRE), around the world, one in six couples has some kind of reproductive dysfunction during their reproductive age. The prevalence of infertility in the world is about 9% among women aged 20-44 years (ESHRE, 2014), with 56% of couples currently seeking infertility treatment [2, 3]
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