Abstract
Background & Aims: Obesity and related co-morbidities such as non-alcoholic fatty liver disease (NAFLD) are increasing dramatically worldwide. Genetic variations in the gene encoding Patatin-like phospholipase domain-containing protein 3 (PNPLA3) which is also known as adiponutrin (ADPN) have been associated with NAFLD affecting hepatic fat content and liver inflammation yet the underlying molecular mechanisms remain unknown. The aim of our study was to investigate whether weight loss affects both hepatic and adipose PNPLA3 expression in severely obese patients before and after laparoscopic gastric banding (LAGB).
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