Abstract
There are speculations that vitamin D may be an important regulator of the energy metabolism. The aim of this study was to evaluate the influence of serum 25(OH)D concentration and nutritional status on the resting metabolic rate. The study group consisted of 223 women with endocrine and/or osteoporotic disorders. The control group consisted of 108 women, clinically healthy. The total 25(OH)D concentration level was measured with an assay using chemiluminescent immunoassay technology. Indirect calorimetry was applied to assess the resting metabolic rate. The mean resting metabolic rate was significantly lower in the group of women with metabolic disorders than in the control group. A correlation was found between serum 25(OH)D levels in healthy subjects and the resting metabolic rate. Significantly higher resting metabolic rate was found in women with normal serum 25(OH)D levels in comparison to subjects with deficient vitamin D levels. The control group demonstrated a relationship between body fat tissue and fat-free body mass and the resting metabolic rate. Both 25(OH)D concentration and body composition were factors influencing the resting metabolic rate in the group of healthy subjects. More research is needed to clarify the relationship between vitamin D status and metabolic rate in individuals with endocrine and osteoporotic disorders.
Highlights
The resting metabolic rate, called resting energy expenditure, is one of components of the total energy demand and it makes up its greater portion
There were no statistical differences in age, weight, waist circumference, Body Mass Index (BMI), and Waist Hip Ratio (WHR)
A significantly higher resting metabolic rate was found in women with normal serum 25(OH)D levels in comparison to subjects with deficient vitamin D levels (1538.5 kcal vs. 1284.9 kcal, Z = 3.7352, p < 0.0001), regardless of any occurrence of endocrine and osteoporotic disorders (Table 2)
Summary
The resting metabolic rate, called resting energy expenditure, is one of components of the total energy demand and it makes up its greater portion. Apart from basic factors that undoubtedly influence the value of the demand, such as fat body mass and fat-free body mass, gender, age, or ethnicity, the variability of resting metabolism in different groups of patients makes it necessary to search for other factors predicting its value. A group of patients with metabolic diseases demonstrated lower values of the basal metabolic rate, which might indicate that there are factors which lower the rate of energy metabolism in these patients and which are not normally taken into account in the assessment of the resting metabolic rate, such as vitamin and mineral deficiencies or hormone imbalances [1–3]. A perusal of the resting metabolic rate literature reveals that considerable information on studies of specific population subgroups, e.g., patients with metabolic disorders, are sparse, especially as far as non-specific factors influencing resting metabolic rate are concerned
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