Respuesta clínica en pacientes con tumores de mama tratadas con radioterapia conformacional postmastectomía en el Instituto Nacional de Cancerología, Colombia

Abstract

IntroductionBreast cancer is the world's leading cause of cancer, with 1,671,149 new cases and 521,907 deaths each year. Adjuvant radiotherapy in patients with T3-T4 tumours or with positive lymph nodes improves locoregional control and overall survival. There is a gap regarding the oncological outcomes and the toxicity derived from the treatments with new radiotherapy techniques used in our Institution since 2010. MethodsA retrospective, descriptive, historical cohort study was conducted on 82 patients with a diagnosis of locally advanced breast cancer treated with post-mastectomy conformational radiotherapy in the Instituto Nacional de Cancerología, between 1 January 2010 and 31 December 2011. ResultsA total of 82 consecutive patients were included in the analysis. At 6 years of follow-up 87.8% (n=72) were still alive, with 3 losses in follow-up. There was a relapse in 30%, and of these 76% were systemic, 12% regional, and 12% regional and systemic. Complications related to radiotherapy were present in 16% of patients. ConclusionThe outcomes of multimodal management of locally advanced breast cancer are similar to those reported by clinical trials. In future studies it will be necessary to evaluate factors associated with regional relapse in this institution.