Abstract
We read with interest the comments of Vas et al. (1) regarding our article (2), which used noninvasive tests of small-fiber structure and function to demonstrate the presence of small-fiber dysfunction prior to large-fiber change in patients with type 1 diabetes. We would like to respond to the following points. Vas et al. (1) raised concerns regarding low laser Doppler imaging of heat-evoked flare (LDIflare) sensitivity for detection of polyneuropathy. In our study, LDIflare was measured using the moorLDI2 instrument (Moor Instruments Ltd., Axminster, U.K.), according to published techniques (3). In a previous study, we have shown …
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