Abstract
MUCH WORK has been done on estrogen production of the ovary and the effects of estrogens upon the uterus since Knauer′s (1900) and Halban′s (1900) historic experiments upon female rabbits and guinea pigs, respectively, in which they transplanted the ovaries to abnormal sites in the body. The lack of conventional atrophy of the genital tract led them to the conclusion that the ovary exerts its in-fluence upon the uterus via an internal secretion. The subsequent literature of the next two decades is reviewed in the early- papers of Loeb (1917), Evans (1922), Marshall (1922), Corner (1923), Allen and Doisy (1927). These basic experimental investigations in rodents were followed by, and later concurrent with, similar studies of the primate uterus (reviewed by Corner, 1939; Allen, 1941; Samuels, 1942; Doisy, 1942). In general, the primate uterus undergoes the same qualitative changes in response to estrogen administration as is reported for the lower animals; i.e., epithelial proliferation, hyperemia, and edema.
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