Abstract
Response: Commentary: Immunogenic Cell Death and Immunotherapy of Multiple Myeloma.
Highlights
We have read with great interest and appreciated the Commentary of Ken Maes and Karine Breckpot pointing out the difficulties to achieve an efficient vaccination using myeloma cells killed by using anti-tumor drugs, in such a way to generate immunogenic corpses able to elicit protective immunity in patients
This relevant work was inadvertently omitted in our previous review on immunogenic cell death (ICD) and immunotherapy of multiple myeloma (Serrano-Del Valle et al, 2019)
In experiments carried out after the publication of our review, we could not prevent induced myeloma in an immunocompetent mouse model that mimics human myeloma development, by vaccination with apoptotic myeloma cells killed with bona fide ICD inducers, which cause ecto-calreticulin exposure
Summary
We have read with great interest and appreciated the Commentary of Ken Maes and Karine Breckpot pointing out the difficulties to achieve an efficient vaccination using myeloma cells killed by using anti-tumor drugs, in such a way to generate immunogenic corpses able to elicit protective immunity in patients. Biochemistry and Molecular and Cell Biology, University of Zaragoza, Zaragoza, Spain A Commentary on Edited by: Lawrence H.
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