Respiratory Muscle Strength as an Indicator of the Severity of the Apnea-Hypopnea Index: Stepping Towards the Distinction Between Sleep Apnea and Breath Holding.

Abstract

Background and objectiveThe aim of this study was to investigate whether the maximum inspiratory and expiratory pressure are correlated with the apnea-hypopnea index (AHI) in patients with obstructive sleep apnea syndrome (OSAS).MethodsFifty-two patients with OSAS were divided into two groups (AHI, events/hours: <30, n=28, versus ≥30, n=24). For each patient, anthropometric characteristics, spirometry parameters, maximum inspiratory (MIP) and expiratory pressure (MEP), and cardiopulmonary function (CPF) parameters (oxygen uptake at rest (VO2), carbon dioxide output (VCO2), heart rate (HR), minute ventilation (VE), tidal volume at inspiratory (TVin) and expiratory (TVex), breath frequency (fβ), end-tidal carbon dioxide pressure (PETCO2), end-tidal oxygen pressure (PETO2), and mean arterial pressure (MAP)) in sitting position for three minutes were recorded. The independent t-test was used to measure the differences between groups (events/hours <30 versus ≥30) and Pearson correlation analysis was used for statistical comparison between parameters.ResultsResults showed differences between groups (AHI, events/h ≥30 versus <30) in MIP (102.0±18.3 versus 91.1±12.1 % of predicted, p=0.013) and CPF parameters TVin (0.8±0.2 versus 0.7±0.1, L, p=0.047), PETCO2 (34.6±4.2 versus 31.4±3.7, mmHg, p=0.007), and MAP (88.4±6.5 versus 82.9±6.2, mmHg, p=0.003). Pearson correlation analysis between respiratory muscle strength (MIP and MEP) and polysomnography (PSG) parameters, MIP is related to AHI (r=.332, p=0.016) and desaturation index (r=.439, p=0.001), as well as MEP to percent of REM sleep stage (r=-.564, p<0.001).ConclusionThe data from the present study support that maximal inspiratory pressure relates to the severity of AHI and intermittent breath-holding during sleep increases the inspiratory muscle strength.