Abstract
α- and β-Cyclodextrins, dissolved in formamide or ethylene glycol, were applied as stationary phases in gas chromatography for the resolution of isomeric cis- and trans-1,2-, 1,3-, and 1,4-dimethylcyclohexanes. It was found that stereoselectivity arising from inclusion of dimethylcyclohexanes in cyclodextrin cavities is more distinct for β-cyclodextrin. Of the two matrix solvents, which influence not only the capacity factors but also the separation factors, formamide is the more efficient medium for stereoselective cyclodextrin inclusion processes. An evaluation of stability constants of (β-cyclodextrin · dimethylcyclohexane) complexes was attempted. Almost complete separation of a mixture containing the six isomers investigated was achieved by using concentrated β-cyclodextrin (1.48 mol. %) in formamide solution.
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