Abstract
Optical resolution of carboxylic acid enantiomers by high-performance liquid chromatography with laser-induced fluorescence detection after chiral derivatization was investigated. Both laser power and time constants influence the detection limit of the fluorophore. The minimum detectable levels of three derivatives of naproxen [4-(aminosulphonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzodioxazole, 4-(N,N-dimethylaminosulphonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole and 4-nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzodiazole derivatives] were in the femtomole-attomole ranges, and the lowest detection limit was obtained with the last derivative.
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