Abstract
Lutein, a dietary carotenoid, is selectively taken up and accumulated in neural tissues. Macular pigment (MP) is considered a surrogate biomarker of lutein levels in the macula and brain. MP density and lutein brain concentrations have been related to better cognitive function, and lutein has also been associated with the reduction of atherosclerotic lesions. Lutein's antioxidant properties may be one of the mechanisms by which it is protective of neural tissue, vasculature, and cognition. Our objective was to evaluate the relationships among MP density, oxidative stress, and cognition in healthy older adults (50 - 84 y, n = 44). MP density was measured using heterochromatic flicker photometry. The resistance of LDL against oxidation (rLDLox), a biomarker of oxidative stress and vascular health, was assessed using lag time of Cu2+induced oxidation. A computerized assessment battery (CANTAB) was used for measures of cognition. Cognitive data were normalized to z-scores; subjects were designated as higher o...
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