Abstract
Objective: Today, bovine pericardium (BP) is extensively investigated as a biomaterial for the generation of various bioimplants. But despite the commercial distribution, and the development of methods to either remove (decellularization) or to mask (chemical cross-linking, e.g. by glutaraldehyde [GA] treatment) the xenogenic antigen epitopes, yet questions around the immunogenic reactivity of BP remain. The aim of this study is the comparison of crucial tissue characteristics i.e. biomechanical properties, the presence of alpha-gal epitopes and residual DNA in acellular vs. GA fixed bovine pericardium.
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