Research round-up

Abstract

In a US case-control study, Frye and colleagues investigated whether the occurrence of antibodies to infectious agents differs between individuals with bipolar disorder (n=1207) and their unaffected counterparts (n=745). Researchers categorised patients as cytomegalovirus (CMV) IgG positive (increased long-term antibody response) and Toxoplasma gondii IgG negative (decreased long-term antibody response) or CMV IgG negative and T gondii IgG positive. Cases with bipolar disorder had higher odds of being CMV IgG positive and T gondii IgG negative than control participants (odds ratio 1·33 [95% CI 1·09–1·62], p=0·004). C-reactive protein concentrations did not differ significantly between participants with bipolar disorder and control participants (p=0·73). Development and validation of multivariable prediction models of remission, recovery, and quality of life outcomes in people with first episode psychosis: a machine learning approachIn our machine learning analysis, we showed that prediction models can reliably and prospectively identify poor remission and recovery outcomes at 1 year for patients with first-episode psychosis using baseline clinical variables at first clinical contact. Full-Text PDF Open AccessCognitive behavioural therapy for irritable bowel syndrome: 24-month follow-up of participants in the ACTIB randomised trialAt 24-month follow-up, sustained improvements in IBS were seen in both CBT groups compared with TAU, although some previous gains were reduced compared with the 12-month outcomes. IBS-specific CBT has the potential to provide long-term improvement in IBS, achievable within a usual clinical setting. Increasing access to CBT for IBS could achieve long-term patient benefit. Full-Text PDF Open Access