Abstract
Mucin is widely expressed in various tissues and organs. The abnormal expression of mucin can be found in many digestive system malignancies, which may be related to the Wnt signaling pathway. Mucins 1 and 4 can promote the occurrence, development and malignancy of various digestive system cancers, and even promote tumor invasion and metastasis. The expression levels of Mucin 2 in different types of tumors are different, and the high or low expression has different role in tumor promotion and inhibition. Mucin 15 is abnormally lowly expressed in digestive system cancers, which involves in tumorigenesis and development as well as invasion and metastasis. Mucins 3, 5 and 6 are also more closely related to digestive system cancers. In this paper, the research progress on the relationship between mucins and digestive system cancers was reviewed. Key words: Mucin; Signal transduction; Digestive system cancer
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