Abstract
Mammalian inner ear hair cells do not have the ability to spontaneously regenerate, so their irreversible damage is the main cause of sensorineural hearing loss. The damage and loss of hair cells are mainly caused by factors such as aging, infection, genetic factors, hypoxia, autoimmune diseases, ototoxic drugs, or noise exposure. In recent years, research on the regeneration and functional recovery of mammalian auditory hair cells has attracted more and more attention in the field of auditory research. How to regenerate and protect hair cells or auditory neurons through biological methods and rebuild auditory circuits and functions are key scientific issues that need to be resolved in this field. This review mainly summarizes and discusses the recent research progress in gene therapy and molecular mechanisms related to hair cell regeneration in the field of sensorineural hearing loss.
Highlights
Shan Xu and Ning Yang*Department of Otolaryngology, The First Hospital of China Medical University, Shenyang, China Reviewed by: Yuhua Zhang, Southeast University, China Wenwen Liu, Shandong University, China Specialty section: This article was submitted to Cellular Neuropathology, a section of the journal
Neural stem cells have the ability to self-renew and differentiate into various types of nerve cells and have been used as a potential treatment for various diseases
The method of regulating the differentiation and development of stem cells through gene editing to promote the regeneration of inner ear hair cells has gradually become a research hotspot in the field of hearing
Summary
Department of Otolaryngology, The First Hospital of China Medical University, Shenyang, China Reviewed by: Yuhua Zhang, Southeast University, China Wenwen Liu, Shandong University, China Specialty section: This article was submitted to Cellular Neuropathology, a section of the journal
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