Abstract
Glioma is the most common fatal primary malignant brain tumor in the central nervous system (CNS). Currently, the main standard treatment is the combination of tumor resection, chemotherapy and radiotherapy. The World Health Organization (WHO) classifies glioma into four grades. Glioblastoma (GBM, WHO Grade 4) is the most aggressive type of glioma, characterized by cell heterogeneity, high proliferation rate, diffuse infiltration ability, and high resistance to chemotherapy drugs. Since the five-year survival rate is extremely low and the recurrence rate is high, some new effective treatment strategies are expected. Pyroptosis is an inflammatory programmed cell death mode. Compared with apoptosis, pyroptosis occurs faster and is accompanied by the release of a large number of pro-inflammatory factors. A large amount of evidence shows that pyrodeath can affect the development of tumor, and has both promoting and inhibiting effects on the development of glioma. In order to further understand the influence of pyroptosis on the glioma, this paper discussed the related studies of pyroptosis and glioma, in order to provide potential tumor treatment strategies based on pyroptosis for glioma patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
