Research Progress on the Effects of PI3K/Akt Pathway on Immune Escape

Abstract

The PI3K/Akt pathway can promote immune escape in tumors, making cancer cells more difficult for the immune system to attack. It is usually possible to regulate the number and function of immune cells by inhibiting apoptosis and T cell activation, and generate immune escape mutations to make cancer cells more resistant to immune monitoring. In-depth understanding of the role of PI3K/Akt pathway in immune escape will help to reveal the mechanism of tumor development, improve the effectiveness of cancer treatment. development, improve the effectiveness of cancer treatment, and restore the immune system's monitoring and attack on cancer cells by inhibiting the activity of PI3K/Akt. In this review, we review the research progress on the effects of G protein-coupled receptor-activated PI3K/Akt pathway on immune escape. This review aims to summarize domestic and international studies that reveal how the PI3K/Akt pathway plays a key role in immune escape, and through in-depth understanding of the role of the PI3K/Akt pathway in immune escape. This review aims to summarize domestic and international studies that reveal how the PI3K/Akt pathway plays a key role in immune escape, and through in-depth understanding of the molecular mechanism, new therapeutic targets can be identified. Scientists from abroad have explored various cancer forms, such as lung, ovarian, and endometrial cancers, etc., so as to provide targeted treatment strategies and increase the applicability of immunotherapy for different cancers; By studying the role of PI3K/Akt pathway, we can explore the potential application of PI3K/Akt pathway for different cancers. By studying the role of PI3K/Akt pathway, we can explore the potential application of existing drugs or new drugs in immunotherapy, so as to improve the diversity of treatment. techniques are combined with clinical data to discover associations between the PI3K/Akt pathway and treatment response in patients to support personalized medicine. Current studies have found that the PI3K/Akt pathway is a key mechanism for immune monitoring of tumor cell escape, and in-depth study of its role is expected to improve the quality of treatment. Current studies have found that the PI3K/Akt pathway is a key mechanism for immune monitoring of tumor cell escape, and in-depth study of its role is expected to improve current immunotherapy strategies and improve patient survival. In the future, whether there are new therapeutic opportunities for PI3K/Akt pathway in immune escape studies, so as to help optimize cancer treatment strategies, improve the efficacy of immunotherapy in future, whether there are new therapeutic opportunities for PI3K/Akt pathway in immune escape studies, so as to help optimize cancer treatment strategies, improve the efficacy of immunotherapy, and improve patient treatment outcomes.