Abstract
Oral microbial community is a typical biofilm. The dental plaque biofilm possess a three-dimensional structure, which is composed of various bacteria and adheres to the surface of the teeth. It has the function of biofilm structure and microbial physiology. Dental plaque biofilm is one of key etiological factors of dental caries and periodontal diseases. A various models have been developed to study the mechanisms and courses of their formation as well as the etiology, prevention and treatment of dental caries. These carious biofilm models help researchers predict the clinical outcome of caries in a controlled and simplified manner. At present, the models for studying caries include single-species biofilm models and multispecies biofilm models in vitro. This review was presented the research progress on establish models of biofilm of dental caries. Key words: Dental plaque; Modles, Biofilm; Multispecies biofilm
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