Abstract
Itch, one of the main E3 ligases, plays an important role in immune responses as a negative regulator in the ubiquitination of PLC-γ, PKC-θ, JunB,and notch. Itch deficiency leads to sever inflammatory disorders and immunological abnormality. Many efforts have been made in disclosing the Itch-promoted protein ubiquitination, modulation of its ligase, transdution of downstream signals in T cell anergy and differentiation in the past years. Key words: Itch; E3 ligase; T helper type 2; Tolerance; Negative regulator
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