Abstract
Objective To summarize the effects of deep brain stimulation(DBS) in the treatment of refractory epilepsy. Methods Engaged in reading foreign references in recent years from 2000 to 2014, with the key words ofdeep brain stimulation, epilepsy, which are related to deep brain stimulation for epilepsy at Pubmed and Ovid Medline database. Results The mechanism of DBS to prevent seizures is probably regulating cortical electric activities by stimulation of brain structures. Animal and clinical studies have stimulated anterior nucleus of the thalamus, hippocampus, centromedian nucleus, caudate nucleus and other sites, which are used to decrease seizures. Patients who have general seizure, multifocal nature of the ictal onset or not candidates for resective treatment are suitable for DBS. Compared with the resective surgery, DBS has many advantages, such as relative noninvasive, reversibility, high safety, alterable parameters and less complications. Conclusions DBS is a promising approach to prevent seizures for the patients who have refractory epilepsy but not candidates for resective surgery. Key words: Epilepsy; Deep brain stimulation; Target
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