Research Progress on Baduanjin Qigong for Depression Prevention and Treatment in the Last Decade

Objective. To investigate the effects of practicing Baduanjin Qigong on different health outcomes. Methods. Six electronic databases were used for literature search through entering the following key words: Baduanjin Qigong, quality of life, sleep quality, and health-related outcomes. Results. Nineteen randomized controlled trials were used for meta-analysis. The aggregated results from this systematic review have shown significant benefits in favour of Baduanjin Qigong on quality of life (SMD, −0.75; 95% CI −1.26 to −0.24; P = 0.004), sleep quality (SMD, −0.55; 95% CI −0.97 to −0.12; P = 0.01), balance (SMD, −0.94; 95% CI −1.59 to 0.30; P = 0.004), handgrip strength (SMD, −0.69; 95% CI −1.2 to −0.19; P = 0.007), trunk flexibility (SMD, −0.66; 95% CI −1.13 to −0.19; P = 0.006), systolic (SMD, −0.60; 95% CI −0.94 to −0.27; P = 0.0004) and diastolic blood pressure (SMD, −0.46; 95% CI −0.73 to −0.20; P = 0.0005), and resting heart rate (SMD, −0.87; 95% CI −1.47 to −0.27; P = 0.005). The aggregated results of meta-analyses examining the effect of Baduanjin Qigong on leg power, cardiopulmonary endurance, and pulmonary function remain unclear because of a small number of studies. Conclusions. The aggregated results from this systematic review show that Baduanjin Qigong practice is beneficial for quality of life, sleep quality, balance, handgrip strength, trunk flexibility, systolic and diastolic blood pressure, and resting heart rate. Further studies are necessary to confirm the effects of Baduanjin Qigong on leg power, cardiopulmonary endurance, and pulmonary function (e.g., vital capacity), while considering a long-term follow-up. Registration Number. This trial is registered with International Prospective Register of Systematic Reviews (PROSPERO): CRD42016036966.

Exercise is an important factor for the treatment and rehabilitation of depression. Traditional Chinese exercise is considered as an effective treatment for depression. In recent years, many studies have shown that Chinese exercise therapy may be safe in the treatment of depression. To evaluate the therapeutic effect of traditional Chinese exercise on depression using network meta-analysis. PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP shop Database, China Biomedical Literature Database, and Wan Fang Data Knowledge Service Platform were included in randomized controlled studies on traditional Chinese exercises for the treatment of depression from the establishment of the library to July 2023. The literature was extracted and assessed for risk of bias using the Cochrane Risk of Bias Assessment and statistically analyzed using Review Manager 5.4 and Stata 14.2. A total of 25 studies involving 3 exercises with a total of 1605 cases were included. The results of the network meta-analysis showed that each exercise significantly reduced the 24-item Hamilton Depression Scale (HAMD-24), Hamilton Anxiety Scale, Beck Depression Inventory, and Self-rating Depression Scale scores. However, conventional treatments have the advantage of improving the sleep quality of patients with depression. The 3 exercises included in this study were effective for depression. Baduanjin and Tai Chi were better at improving the outcomes related to depression and anxiety. The effect of sleep quality intervention was slightly worse. Larger, high-quality randomized controlled trials are needed to compare interventions across exercises in a more granular manner.

The present study investigated the effectiveness of Baduanjin Qigong on symptoms related to gait, functional mobility and sleep in Parkinson disease (PD) patients. A total of 100 patients (age 67.53 ± 8.56 years, range 55-80 years) with mild to moderate PD were randomly assigned to two groups. Participants in the Baduanjin Qigong group (BQG) received a Baduanjin Qigong program, consisting of four 45-min sessions each week and daily walking 30 min for 6 months. Participants in the control group were carried out daily walking for 30 min. Pre- and post-intervention testing was carried out to assess sleep quality, fatigue, functional mobility and gait performance in these participants. After the 6-month Baduanjin Qigong intervention, the BQG showed sleep quality improvements in the Unified Parkinson's Disease Rating Scale score (P = 0.049), Parkinson's Disease Sleep Scale-2 (PDSS-2) total score (P = 0.039), Motor Symptoms at Night (PDSS-2) score (P = 0.039), PD Symptoms at Night (PDSS-2) score (P = 0.029), Disturbed Sleep (PDSS-2) score (P = 0.037). The BQG showing functional mobility capacity greater improvements in the Berg Balance Scale (P = 0.041) and 6-minute walk test (P = 0.042), and greater decrease in the Timed Up & Go (s; P = 0.046). The BQG showing gait function increased in the gait speed (m/s; P = 0.011). However, this was not the case for the control group, which remained at the same level as pretest performance. BQG improved the gait performance, functional mobility and sleep quality in older adults with PD at the 6-month follow up. It is as an alternative home exercise program for older adults in rehabilitation for PD. Geriatr Gerontol Int 2016; 16: 911-919.

BackgroundChronic insomnia (CI) is a mind-body disease that is commonly defined as a state of having disturbed daytime activities due to poor nighttime sleep quality. Baduanjin qigong (BDJQG) is widely used for CI in China. However, there is little scientific evidence to evaluate its effects on the hyperarousal state, which is closely associated with improved sleep quality.ObjectiveThe objective of the trial is to assess the therapeutic effects of BDJQG on sleep quality in patients with CI.MethodsA randomized controlled trial will be conducted on 86 patients, who will be divided into a BDJQG group and a cognitive behavioral therapy for insomnia group at a ratio of 1:1. Interventions in both groups will be given to the participants 7 times a week for 8 weeks, and the participants will be followed up for 4 weeks. The primary outcome is the change in the Pittsburgh Sleep Quality Index from baseline to week 8. The secondary outcomes are the changes in the Hyperarousal Scale, Insomnia Severity Index, Fatigue Scale-14, wrist actigraphy, salivary cortisol level, and functional magnetic resonance imaging from baseline to week 8. All main analyses will be carried out on the basis of the intention-to-treat principle.ResultsThis study was funded from January 2023. As of the submission of the manuscript, there were 86 participants. Data collection began in April 2023 and will end in January 2024. Data analysis is expected to begin in January 2024, with the publication of results expected in February 2024.ConclusionsThis study will present data concerning the clinical effects of BDJQG on CI. The results will help to demonstrate whether BDJQG is an effective therapy for improving sleep quality in association with a decreased hyperarousal level as a possible underlying mechanism. This study will provide much-needed knowledge for complementary and alternative therapy for patients with CI.Trial RegistrationChina Clinical Registration Agency ChiCTR2300069241; https://chictr.org.cn/bin/project/ChiCTR2300069241International Registered Report Identifier (IRRID)PRR1-10.2196/53501

Introduction: Fibromyalgia is marked by widespread chronic pain, fatigue, and disrupted sleep, significantly impacting quality of life. This study aimed to explore the effect of Baduanjin Qigong (BQ) on impact of the disease and quality of sleep in elderly patients with fibromyalgia. Methods: The study employed a semi-experimental design. A total of thirty-four elderly female patients with fibromyalgia were recruited through convenience sampling and allocated into two intervention groups: BQ group (n = 17) and a walking group (n = 17). The BQ protocol was conducted for 12 weeks, with sessions held three times a week. The walking group participated in a 12 week fitness walking program. Impact of the disease and quality of sleep were assessed at baseline and after 12 weeks using The Revised Fibromyalgia Impact Questionnaire (FIQR) and the Pittsburgh Sleep Quality Index (PSQI). Data were analyzed using paired t-test and independent t-test. Results: The significant improvements were observed in PSQI total (t (16) = 3.65, p = 0.002), FIQR (t (16) = 3.76, p = 0.002), FIQR function (t (16) = 2.16, p = 0.04), FIQR symptoms (t (16) = 2.957, p = 0.009) in BQ group. There was a significant difference between the average post-test data of the walking group and BQ group in daytime dysfunction, with the BQ group performing better than the walking group (p ≤ 0.05). Conclusion: BQ significantly improves fibromyalgia impact and sleep quality in elderly patients and reduces daytime dysfunction more effectively than walking. However, it is not superior to walking in other aspects of disease impact and sleep quality enhancement.

Background:Long term insomnia and low sleep quality often lead to depression, anxiety and other negative emotions, and often interact with each other. Many studies have confirmed the effectiveness of acupuncture in the treatment of insomnia comorbid with emotional disorders, but its specific mechanism needs to be further explored. Resting-state functional magnetic resonance (rsfMRI) is an important means to study the changes of brain activity. However, the results are inconsistent and lack of systematic evaluation and analysis.Methods:Nine databases will be searched, including PubMed, EMBASE, EBSCOhost-medline, Web of Science, Cochrane Library, China National Knowledge Infrastructure, VIP Database and Wan-Fang Database, Chinese Biomedical Literature Database from inception to January 2021. And screening clinical registration platform related research, in order to obtain more relevant studies. The outcomes include the change of rs-fMRI, sleep quality, depression, and anxiety. Quality assessment of the included studies will be performed according to the Cochrane Risk of Bias tool. Evidence quality will be assessed by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. RevMan software (Version 5.3) and stata13.1will be used for statistical analyses. Subgroup analysis will be performed if necessary. If the data is insufficient, qualitative synthesis will be conducted instead of quantitative synthesis.Results:This study will analyze the effect of acupuncture on the brain activity changes, improvement of sleep quality and clinical symptoms of anxiety and depression with insomnia comorbid with emotional disorders.Conclusion:This study used meta-analysis method to explore the characteristics of acupuncture on brain activity changes in insomnia comorbid with emotional disorders, so as to provide effective evidence for clarifying its pathogenesis.

Coronavirus disease-2019 (COVID-19) is a highly infectious respiratory disease that leads to respiratory, physical, and psychological dysfunction in patients. Respiratory rehabilitation is an important intervention as well as cure for clinical patients. With increased understanding of COVID-19 and the accumulation of clinical experience, we proposed recommendations for respiratory rehabilitation in adults with COVID-19 based on the opinions of frontline clinical experts involved in the management of this epidemic and a review of the relevant literature and evidence. Our recommendations are as follows: 1. for inpatients with COVID-19, respiratory rehabilitation would relieve the symptoms of dyspnea, anxiety, and depression and eventually improve physical functions and the quality of life; 2. for severe/critical inpatients, early respiratory rehabilitation is not suggested; 3. for patients in isolation, respiratory rehabilitation guidance should be conducted through educational videos, instruction manuals, or remote consultation; 4. assessment and monitoring should be performed throughout the respiratory rehabilitation process; 5. proper grade protection should be used following the present guidelines. These recommendations can guide clinical practice and form the basis for respiratory rehabilitation in COVID-19 patients.

Introduction: Major Depressive Disorder is a prevalent mental disorder, significantly contributing to the number of disability-adjusted life years and years of healthy life lost to disability. The efficacy of currently available treatment modalities is limited by adverse effects and suboptimal treatment response, highlighting the need for additional therapeutic options. A growing body of evidence suggests that numerous nutraceuticals of natural origin may be implemented in the treatment of depression. Aim of the study: The aim of the study was to compile and analyze current literature regarding the supplementation with polyunsaturated fatty acids, probiotics, polyphenolic antioxidants, vitamins and minerals in treatment and prevention of depression, both as an adjunct to antidepressants and as a standalone therapy. Methods and materials: A literature search was conducted using the PubMed database and Google Scholar, focusing on recent publications, primarily from the past 10 years. Additionally, references from selected articles were included in the analysis. Summary: Recent scientific literature suggests that all analyzed nutraceuticals may be effectively used in the treatment of depression. However, further research, particularly large-scale randomized controlled studies, is crucial to confirm the efficacy of these compounds as treatment modalities.

The effect of Baduanjin Qigong combined with five-elements music on anxiety and quality of sleep in asymptomatic patients with COVID-19 infection: A randomised controlled trial

The aim of this randomised double-blinded controlled trial was to investigate the effect of Baduanjin Qigong (BQG) and transcranial direct current stimulation (tDCS) on quality of sleep and disease impact in elderly patients with fibromyalgia (FM). A randomised, double-blind, clinical trial conducted, involving 68 elderly female and male patients with FM were selected through convenience sampling, and randomly assigned into one of four intervention groups: (1) BQG combined with the tDCS group (BQGT) (n=17); (2) BQG combined with the sham tDCS group (BQGS) (n=17); (3) walking combined with tDCS (WAT) (n=17); and (4) walking combined with sham tDCS (WAS) (n=17). All participants were assessed at baseline and 12 weeks post-test for disease impact and sleep quality using the Revised FM Impact Questionnaire (FIQR) and the Pittsburgh Sleep Quality Index (PSQI), respectively. Data were analysed using Multivariate Analysis of Variance (MANOVA). Sleep quality was significantly associated with individual interventions (F(21, 167) =2.88, p<0.05, Wilk's Λ=0.411, partial η²=0.257). FIQ scores also showed significant associations (F(3, 64) =4.47, p< 0.05, Wilk's Λ=0.210, partial η²=0.173). Treatments significantly affected FIQR (F(3) =3.901, p<0.05, partial η²=0.155), FIQR symptoms (F(3) =4.458, p<0.05, partial η² =0.173), PSQI total (F(3) =6.044, p<0.05, partial η² =0.221), sleep disturbances (F(3) =10.314, p<0.05, partial η²=0.326), and sleep dysfunction (F(3) =11.487, p<0.05, partial η²=0.350). Significant differences were found between WAT and WAS for FIQR (p=0.016), and between BQGT and WAS (p=0.049), and WAT and WAS (p=0.009) for FIQR symptoms. PSQI total showed significant differences between BQGT and BQGS (p=0.030), BQGT and WAT (p=0.039), and BQGT and WAS (p=0.000). Significant differences in sleep disturbances were observed between BQGT and BQGS (p=0.000), BQGT and WAT (p=0.001), and BQGT and WAS (p=0.000). Further differences were found between BQGT and WAS (p=0.000), BQGS and WAS (p=0.004), and WAT and WAS (p=0.000). This study shows that physical activity interventions, and especially BQG, significantly improve sleep quality and disease symptoms, with notable effects on PSQI scores and FIQR, especially when combined with tDCS across different groups. These findings highlight the importance of combining interventions into holistic brain-body treatments for managing FM effectively.

Effect of five-elements music therapy combined with Baduanjin qigong on patients with mild COVID-19.

Since the publication in 2000 of APA’s Practice Guideline for the Treatment of Patients With Major Depressive Disorder (2nd Edition) (1), two important safety concerns have emerged (hepatotoxicity with nefazodone, and suicide risk and antidepressants), and two new antidepressants have been approved for use (escitalopram and duloxetine). This watch describes these developments as well as evidence that has accrued since 2000 in other areas related to the treatment of major depressive disorder.

Technologies for repairing peripheral nerve injury*: Progress in domestic and foreign investigations

Chemotherapy-induced peripheral neuropathy (CIPN) occurs in 68.1% of patients within the first month of undergoing chemotherapy; however, standardized treatment for CIPN has not been established yet. The efficacy of acupuncture, a widely used treatment for CIPN in South Korea, has not been studied sufficiently. This study aimed to review the studies that evaluated the efficacy of acupuncture or electroacupuncture (EA) in treating CIPN. A literature search was performed on relevant international databases - MEDLINE, Embase, the Allied and Complementary Medicine Databases, and China National Knowledge Infrastructure - as well as Korean databases - the National Digital Science Library, Oriental Medicine Advanced Searching Integrated System, DBpia, and Korean Studies Information Service System. Randomized controlled trials (RCTs) that aimed to treat CIPN symptoms with acupuncture or EA and set not only a control group with a conventional pharmacological treatment or injection, but also a placebo control or sham-acupuncture group, were included. Meta-analysis was conducted to elucidate the efficacy of acupuncture/EA on the basis of symptom score. Of the 13 studies included in the literature review, 12 RCTs compared acupuncture and pharmacological treatments. There were 3 EA RCTs, but only 1 RCT compared EA and sham-EA. A total of 832 participants were included in these studies. Five RCTs showed that acupuncture was more effective than pharmacological treatment in terms of efficacy rate. Regarding the risk of bias summary, the quality of included studies was poor. Only 1 study compared the efficacy of EA and sham EA; therefore, the specific efficacy of acupuncture could not be elucidated. Acupuncture is safe, but the symptom-alleviating effect on CIPN can hardly be determined because of methodological deficiencies of the included studies. In terms of the clinical efficacy rate, acupuncture was more effective than conventional pharmacological treatments. CRD42018111509.

Effects of traditional Chinese exercises and general aerobic exercises on older adults with sleep disorders: A systematic review and meta-analysis