Abstract
ABSTRACT Sepsis is considered a life-threatening organ dysfunction resulting from a dysregulation of the body's response to the infection, a syndrome of physiological, pathological, and biochemical abnormalities caused by infection. The prevention and treatment of sepsis-related acute lung injury has become a hot spot in sepsis research in recent years. Neutrophil elastase (NE) is a multifunctional serine protease released by neutrophils cells, which can participate in the regulation of the inflammatory response in the body and directly affect the occurrence and development of inflammation. This article reviews the pathogenesis of sepsis-related lung injury and the mechanism of action, clinical application and prospect of neutrophil elastase inhibitor (NEI).
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