Abstract

With the development of modern biotechnology, new vaccines like recombinant protein vaccine and synthetic peptide vaccine are emerging, all requiring safe and effective adjuvants to enhance their immunogenicity. Among new adjuvants, oil-in-water emulsion adjuvant, such as MF59 and AS03 approved for human use in Europe and US, is a new hot spot, which can enhance immune response and are well-tolerated. This review focuses on research progress of oil-in-water emulsion adjuvant in order to provide reference for the research of new adjuvants with high effectiveness and low toxicity. Key words: Adjuvant, immunologic; Oil-in-water emulsion; Influenza vaccines

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