Abstract

The NLRP3 inflammasome belongs to pattern recognition receptor.It can be used for detecting pathogen and stress signals (danger-associated molecular patterns,DAMPs),NLRs with ASC (apoptosis-associated speck-like protein containing a CARD) form a multiprotein complex:the NLRP3 inflammasome.The NLRP3 inflammasome activate caspase- 1 which is a prerequisite for the maturation of interleukin ( IL)- 1 β and IL- 18.Recent findings show that the NLRP3 inflammasome not only is an innate responder to pathogenic and danger signals,but also can affect the adaptve immune response.The cytokines induced by NLRP3 inflammasome,such as IL-1β and IL-18 play an important role in the induction of antigen-specific cellular and humoral immunity.In this article,the role of NLRP3 inflammasome in regulating adaptive immunity is reviewed. Key words: Receptors, pattern recognition; Inflammasomes; Adaptive immunity

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