Research progress of NF-κB’s activation and oxidative stress and antioxidants in the treatment of acute pancreatitis

Abstract

Acute pancreatitis is a kind of acute inflammatory medium reaction caused by pancreatic enzyme activation within pancreatic tissue by its own digestion. It may induce systemic inflammatory medium reaction and cause multiple organfailure, even cause death of the patients with acute pancreatitis. In recent years, a lot of research data indicate that activation of NF-kappa B and oxidative stress have played an important role in the occurrence and development of acute pancreatitis. Hence treatment of antioxidant supplement to patients with acute pancreatitis is deemed to a new research direction. Multiple studies have shown that simplex or associated antioxidant therapy is beneficial to acute pancreatitispatient with lower infection rate and other complications. At the same time, more studies of antioxidants such as various plant extracts in animal models have made progress. By reviewing the relevant experimental and clinical literature, the activation of NF-kappa B and the effect of oxidative stress on acute pancreatitis and the progress of antioxidant therapy for acute pancreatitis are reviewed. Key words: Antioxidant; NF-kappa B; Oxidative stress; Reactive oxygen species; Acute pancreatitis