Abstract
Digestive system neoplasms are the most common malignant tumors worldwide. MicroRNAs (miRNA, miR) are a kind of endogenous, non coding single-stranded RNA, which can play an oncogene or tumor suppressor gene function in the initiation and the progression of the malignant tumor. Studies have shown that miRNA plays an important role in the occurrence and development of digestive system neoplasms. The role of miR-135a in the tumorigenesis and development of digestive system neoplasm has aroused widespread concern. Studies have confirmed that miR-135a can regulate the expression of its target genes to affect some key biological processes such as cell proliferation, apoptosis, invasion and metastasis of digestive system neoplasms. In this paper, we mainly reviewed recent research progress of miR-135 in digestive system neoplasms. Key words: MicroRNA-135a; Digestive system neoplasms; Cell proliferation; Apoptosis; Invasion; Metastasis
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