Abstract

At present, the poor prognosis of conventional chemotherapy for most malignant tumors is an important problem for clinical work, but the tumor cell resistance is one of the important reasons for the failure of chemotherapy. The existence of tumor stem cell resistance can cause tumor cells to reduce the sensitivity of most chemical drugs after a positive chemotherapy, the recurrence and metastasis of tumor can ultimately endanger the patient's life. The formation mechanism of drug resistance of tumor cells is complex. And there are many signal molecules and signal transduction pathways related with the formation mechanism of drug resistance, but the concrete mechanism is not yet fully clarified. MicroRNA (miRNA) and the formation of tumor drug resistance are highly correlated according to relevant researches. MiRNA can targetedly regulate drug resistance mechanism and plays a very important role in reducing drug resistance of tumor cells. This article intends to review the research advances of the formation mechanism of miRNA resistant tumor cells. Key words: MicroRNAs; Negative regulation; Tumor cell; Drug resistance, neoplasm

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